abstract：:We showed that nucleotide sequences coding for linear B-cell epitopes of human immunodeficiency virus type 1 (HIV1) gp120 protein are enriched with codons containing cytosine and guanine in their first and second codon positions. Guanine and cytosine are the most mutable nucleotides in HIV1 genes (due to APOBEC3 and A...

journal_title：Molecular immunology

authors： Khrustalev VV

更新日期：2010-04-01 00:00:00

abstract：:The hyper-IgE syndrome (HIES) is a rare primary immunodeficiency characterized by a highly elevated serum IgE, recurrent staphylococcal skin abscesses and cyst-forming pneumonia. Non-immunological abnormalities, including a distinctive facial appearance, hyperextensive joints, scoliosis, fracture following minor traum...

journal_title：Molecular immunology

authors： Papanastasiou AD,Mantagos S,Papanastasiou DA,Zarkadis IK

更新日期：2010-04-01 00:00:00

abstract：:CD20 is an important target for monoclonal antibody therapy of B-cell malignancies and for some autoimmune disorders. Though there is interest in evaluating the induction of active immunity to CD20 in the mouse model, the CD20 extracellular domain (ECD) has significant secondary and tertiary structure which make it di...

journal_title：Molecular immunology

authors： Oscherwitz J,Gribbin TE,Cease KB

更新日期：2010-04-01 00:00:00

abstract：:C-reactive protein (CRP) is a pattern recognition molecule that binds several microbial and host ligands. Ligand-bound CRP activates the complement system via the classical pathway. Previously, we identified human complement factor H-related protein 4 (CFHR4), a member of the factor H protein family, as a CRP binding ...

journal_title：Molecular immunology

authors： Hebecker M,Okemefuna AI,Perkins SJ,Mihlan M,Huber-Lang M,Józsi M

更新日期：2010-03-01 00:00:00

abstract：:The present study reports the characterization of Ls-Stylicin1, a novel antimicrobial peptide from the penaeid shrimp, Litopenaeus stylirostris. The predicted mature peptide of 82 residues is negatively charged (theoretical pI=5.0) and characterized by a proline-rich N-terminal region and a C-terminal region containin...

journal_title：Molecular immunology

authors： Rolland JL,Abdelouahab M,Dupont J,Lefevre F,Bachère E,Romestand B

更新日期：2010-03-01 00:00:00

abstract：:Macrophage migration is mediated by complex cellular signaling processes and cytoskeleton re-arrangement. In particular, recent advances indicate that the innate immunity signaling process plays a key role in the regulation of macrophage migration. In this report, we have provided evidence demonstrating the involvemen...

journal_title：Molecular immunology

authors： Gan L,Li L

更新日期：2010-03-01 00:00:00

abstract：:Interleukin (IL)-23 is a heterodimeric cytokine composed of the IL-23-specific subunit p19 and the p40 subunit which also constitutes part of IL-12. IL-23 propagates development of Th17 cells, a novel T cell subset which produces IL-17 but no interferon-gamma or IL-4. For both, IL-23 and IL-23-driven IL-17, a crucial ...

journal_title：Molecular immunology

authors： Sender LY,Gibbert K,Suezer Y,Radeke HH,Kalinke U,Waibler Z

更新日期：2010-03-01 00:00:00

abstract：:Chemokines are key regulators of migration and consequent activation of migrating leukocytes. CC chemokines constitute the largest chemokine group with 24-28 members in mammalian species, and even more in teleost fish, with up to 81 members in zebrafish Danio rerio. Further studies concerning fish chemokine genes will...

journal_title：Molecular immunology

authors： Cuesta A,Dios S,Figueras A,Novoa B,Esteban MA,Meseguer J,Tafalla C

更新日期：2010-03-01 00:00:00

abstract：:Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vbeta6 expressing T cells in the thymus of Mtv-7(+) DBA/2 (H2(d)) mice through negative selection. We found that in Mtv-7(-) BALB/c (H2(d)) mice, Vbeta6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEY...

journal_title：Molecular immunology

authors： Kilgannon P,Novak Z,Fotedar A,Singh B

更新日期：2010-02-01 00:00:00

abstract：:IFN-gamma plays an essential role in the IL-12/IL-23/IFN-gamma pathway that is required for the defense against intracellular pathogens. In the IFN-gammaR1 several amino acid substitutions have been reported that abrogate IFN-gamma signaling. These substitutions can lead to a null phenotype and enhanced susceptibility...

journal_title：Molecular immunology

authors： van de Wetering D,de Paus RA,van Dissel JT,van de Vosse E

更新日期：2010-02-01 00:00:00

abstract：:Dendritic cells (DCs) serve to maintain peripheral tolerance under steady state conditions. Upon triggering by activation signals they initiate strong immune responses. The activation of DCs is accompanied by a rapid upregulation of proinflammatory cytokines, which were shown in other cell types to be regulated by mec...

journal_title：Molecular immunology

authors： Bros M,Wiechmann N,Besche V,Art J,Pautz A,Grabbe S,Kleinert H,Reske-Kunz AB

更新日期：2010-02-01 00:00:00

abstract：:Previous studies showed that P2 receptors are involved in neutrophil migration via stimulation of chemokine release and by facilitating chemoattractant gradient sensing. Here, we have investigated whether these receptors are involved in LPS-induced neutrophil transendothelial migration (TEM) using a Boyden chamber whe...

journal_title：Molecular immunology

authors： Kukulski F,Ben Yebdri F,Bahrami F,Fausther M,Tremblay A,Sévigny J

更新日期：2010-02-01 00:00:00

abstract：:In this work, we show that P2 nucleotide receptors control lipopolysaccharide (LPS)-induced neutrophil migration in the mouse air pouch model. Neutrophil infiltration in LPS-treated air pouches was reduced by the intravenous (iv) administration of the non-selective P2 receptor antagonist PPADS but not by suramin and R...

journal_title：Molecular immunology

authors： Kukulski F,Ben Yebdri F,Bahrami F,Lévesque SA,Martín-Satué M,Sévigny J

更新日期：2010-01-01 00:00:00

abstract：:Different proteins, even without sequence similarity, still can contain similar surface regions involved in protein-protein interactions with common target. These regions can serve as structural determinants of cross-reactivity and molecular mimicry. Molecular mimicry, defined as the process in which structural proper...

journal_title：Molecular immunology

authors： Iakhiaev MA,Iakhiaev AV

更新日期：2010-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II proteins have been in the focus of interest for immunologists, biochemists, cell biologists, and structural biologists for decades. With dozens of entries in the Protein Data Bank, their crystal structures are now sufficiently well understood, while their dynamic p...

journal_title：Molecular immunology

authors： Yaneva R,Schneeweiss C,Zacharias M,Springer S

更新日期：2010-01-01 00:00:00

abstract：:DC-SIGN (dendritic cell-specific ICAM-3-grabbing non-integrin) is a myeloid pathogen-attachment factor C-type lectin which recognizes mannose- and fucose-containing oligosaccharide ligands on clinically relevant pathogens. Intracellular signaling initiated upon ligand engagement of DC-SIGN interferes with TLR-initiate...

journal_title：Molecular immunology

authors： Sierra-Filardi E,Estecha A,Samaniego R,Fernández-Ruiz E,Colmenares M,Sánchez-Mateos P,Steinman RM,Granelli-Piperno A,Corbí AL

更新日期：2010-01-01 00:00:00

abstract：:Host-derived macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infection, especially in malarial anemia. Although two Plasmodium parasite-derived MIF orthologs, Plasmodium falciparum MIF and P. berghei MIF were identified recently, the crystal structure and the precise rol...

journal_title：Molecular immunology

authors： Shao D,Zhong X,Zhou YF,Han Z,Lin Y,Wang Z,Bu L,Zhang L,Su XD,Wang H

更新日期：2010-01-01 00:00:00

abstract：:The effect of antibody affinity on molecular forms of immune complexes was investigated by measuring antigen-antibody interactions using surface plasmon resonance (SPR), electrospray ionization time-of-flight mass spectrometry under non-denaturing conditions (MS), analytical ultracentrifugation (AUC), and transmission...

journal_title：Molecular immunology

authors： Oda M,Uchiyama S,Noda M,Nishi Y,Koga M,Mayanagi K,Robinson CV,Fukui K,Kobayashi Y,Morikawa K,Azuma T

更新日期：2009-12-01 00:00:00

abstract：:The preTCR, gammadeltaTCR, and alphabetaTCR are the three isoforms of the T cell antigen receptor that are expressed during thymocyte development. Signaling by these isoforms is required at different stages of T cell development for lineage commitment, thymocyte maturation, and repertoire selection. All three isoforms...

journal_title：Molecular immunology

authors： Laird RM,Hayes SM

更新日期：2009-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection afflicts over 350 million people worldwide and is a leading cause of hepatitis, cirrhosis and hepatocellular carcinoma. HBV replicates noncytopathically in hepatocytes, and most of the hepatic injury is caused by the immune response to the virus. While most studies focused on the adap...

journal_title：Molecular immunology

authors： Qu Z,Liang X,Liu Y,Du J,Liu S,Sun W

更新日期：2009-12-01 00:00:00

abstract：:Peach non-specific lipid transfer protein (Pru p 3; nsLTP) has been characterized as the major food allergen in the adult Mediterranean population. Its wheat homologous protein, Tri a 14 has a relevant inhalant allergen in occupational baker's asthma. Different sensitization patterns to these allergens have been found...

journal_title：Molecular immunology

authors： Tordesillas L,Pacios LF,Palacin A,Quirce S,Armentia A,Barber D,Salcedo G,Diaz-Perales A

更新日期：2009-12-01 00:00:00

abstract：:Lysozyme is an important component of the insect non-specific immune response against bacteria that is characterized by its ability to break down bacterial cell-walls. By searching an EST database from the fall armyworm, Spodoptera frugiperda (Negre et al., 2006), we identified five sequences encoding proteins of the ...

journal_title：Molecular immunology

authors： Chapelle M,Girard PA,Cousserans F,Volkoff NA,Duvic B

更新日期：2009-12-01 00:00:00

abstract：:While the antigenic variability is the major obstacle for developing vaccines against antigenically variable pathogens (AVPs) and cancer, this issue is not addressed adequately in current vaccine efforts. We developed a novel variable epitope library (VEL)-based vaccine strategy using immunogens carrying a mixture of ...

journal_title：Molecular immunology

authors： Pedroza-Roldan C,Charles-Niño C,Saavedra R,Govezensky T,Vaca L,Avaniss-Aghajani E,Gevorkian G,Manoutcharian K

更新日期：2009-12-01 00:00:00

abstract：:An initial bioinformatics investigation followed by cloning and sequencing analysis, has led to the identification of three novel members (omDB-2, omDB-3, omBD-4) of the beta-defensin family in rainbow trout (Oncorhynchus mykiss). The contiguous sequences could be translated to give predicted peptides of 62 (omDB-2), ...

journal_title：Molecular immunology

authors： Casadei E,Wang T,Zou J,González Vecino JL,Wadsworth S,Secombes CJ

更新日期：2009-10-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is critical for immunoglobulin (Ig) diversification in B cells. The majority of evidence supports the model that AID modifies Ig genes at the DNA level by deaminating cytosines into uracils. The mutagenic activity is largely restricted to Ig genes to avoid genomic damage in ...

journal_title：Molecular immunology

authors： Kim Y,Tian M

更新日期：2009-10-01 00:00:00

abstract：:The T cell receptor (TCR) detects the presence of infectious pathogens and activates numerous intracellular signaling pathways. Protein tyrosine phosphorylation and ubiquitination serve as key regulatory mechanisms downstream of the TCR. Negative regulation of TCR signaling pathways is important in controlling the imm...

journal_title：Molecular immunology

authors： Carpino N,Chen Y,Nassar N,Oh HW

更新日期：2009-10-01 00:00:00

abstract：:The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II molecules within antigen presenting cells by generating a "peptide-receptive" MHC class II conformation (MHC(receptive)) to which peptides readily bind and rapidly unbind. While recent work has uncovered the determinants of DM reco...

journal_title：Molecular immunology

authors： Narayan K,Su KW,Chou CL,Khoruzhenko S,Sadegh-Nasseri S

更新日期：2009-09-01 00:00:00

abstract：UNLABELLED:C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also proposed as a decoy receptor for C5a, an inflammatory mediator, b...

journal_title：Molecular immunology

authors： Cui W,Simaan M,Laporte S,Lodge R,Cianflone K

更新日期：2009-09-01 00:00:00

abstract：:Infectious salmon anaemia virus (ISAV) is a marine orthomyxovirus of significant interest not only as a cause of a fatal disease of farmed Atlantic salmon resulting in severe economic losses to the aquaculture industry, but also as the only poikilothermic orthomyxovirus. ISAV targets vascular endothelial cells and mac...

journal_title：Molecular immunology

authors： Workenhe ST,Hori TS,Rise ML,Kibenge MJ,Kibenge FS

更新日期：2009-09-01 00:00:00

abstract：:Mannose-binding lectin (MBL) and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pa...

journal_title：Molecular immunology

authors： Garred P,Honoré C,Ma YJ,Munthe-Fog L,Hummelshøj T

更新日期：2009-09-01 00:00:00

abstract：:The potency of a T cell is determined in large part by two interactions, binding of a cognate peptide to the MHC, and binding of the T cell receptor (TCR) to this pepMHC. Various studies have attempted to assess the relative importance of these interactions, and to correlate the corresponding binding parameters with t...

journal_title：Molecular immunology

authors： Bowerman NA,Crofts TS,Chlewicki L,Do P,Baker BM,Christopher Garcia K,Kranz DM

更新日期：2009-09-01 00:00:00

abstract：:Intravenous drug use has become the principal route of hepatitis C virus (HCV) transmission due to the sharing of infected needles. In this study, we analyzed the distribution of HLA-KIR genotypes among 160 Puerto Rican intravenous drug users (IDUs) with HCV infection and 92 HCV-negative Puerto Rican IDUs. We found a ...

journal_title：Molecular immunology

authors： Zúñiga J,Romero V,Azocar J,Terreros D,Vargas-Rojas MI,Torres-García D,Jiménez-Alvarez L,Vargas-Alarcón G,Granados-Montiel J,Husain Z,Chung RT,Alper CA,Yunis EJ

更新日期：2009-08-01 00:00:00

abstract：:Chicken host defense peptide cathelicidin-2 (CATH-2) is known to exert antimicrobial and immunomodulatory activities and consists of two alpha-helices connected by a hinge region. Here we report the biological properties of the separate alpha-helical segments and the importance of the proline residue in the hinge regi...

journal_title：Molecular immunology

authors： van Dijk A,Molhoek EM,Veldhuizen EJ,Bokhoven JL,Wagendorp E,Bikker F,Haagsman HP

更新日期：2009-08-01 00:00:00

abstract：:A recent publication in Molecular Immunology by Leo and Goldman doi:10.1016/j.molimm.2009.02.024 has shown that the Escherichia coli immunoglobulin-binding (Eib) proteins are receptors for IgG and IgA. We would like to highlight important issues that were not addressed in their recent manuscript whilst providing possi...

journal_title：Molecular immunology

authors： Pleass RJ

更新日期：2009-07-01 00:00:00

abstract：:The mammalian interleukin (IL)-6 family of cytokines consist of eight class-I helical cytokines and are major players in hematopoiesis, as well as in neuroendocrine and immune systems, and have pro- and anti-inflammatory properties. We have identified a novel fish CNTF-like molecule, for the first time, as well as the...

journal_title：Molecular immunology

authors： Wang T,Secombes CJ

更新日期：2009-07-01 00:00:00

abstract：:We have previously shown that immunization with SIV-, SHIV-, or HA (influenza hemagglutinin)-virus-like particles (VLPs) elicits a strong humoral immune response in mice. However, little is known about the action VLPs exert on immune effector cells, including B cells. In this study, we found that all three types of VL...

journal_title：Molecular immunology

authors： Zhang S,Cubas R,Li M,Chen C,Yao Q

更新日期：2009-06-01 00:00:00

abstract：:To understand the mechanism of action of the chaperone protein tapasin, which mediates loading of high-affinity peptides onto major histocompatibility complex (MHC) class I molecules in the antiviral immune response, we have performed numerical simulations of the class I-peptide binding process with four different mec...

journal_title：Molecular immunology

authors： Schneeweiss C,Garstka M,Smith J,Hütt MT,Springer S

更新日期：2009-06-01 00:00:00

abstract：:Art v 3, the lipid-transfer protein (LTP) of Artemisia vulgaris pollen is a relevant allergen showing frequent cross-reactivity with homologues in other plants. Here we report the identification of four full-length Art v 3 sequences obtained by cDNA cloning using mass spectrometry-based sequencing. Two isoforms, Art v...

journal_title：Molecular immunology

authors： Gadermaier G,Harrer A,Girbl T,Palazzo P,Himly M,Vogel L,Briza P,Mari A,Ferreira F

更新日期：2009-06-01 00:00:00

abstract：:Malignant transformation of hepatocytes is frequently associated with upregulation of HLA-A expression. Currently there is no information available regarding the mechanisms underlying this phenotypic change. We investigated HLA-A expression in 165 paraffin embedded tissues and 21 fresh tissues from liver cancer patien...

journal_title：Molecular immunology

authors： Shen Y,Xia M,Zhang J,Xu L,Yang J,Chen A,Miao F,Ferrone S,Xie W

更新日期：2009-06-01 00:00:00

abstract：:Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(-/-)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a ...

journal_title：Molecular immunology

authors： Paixão-Cavalcante D,Hanson S,Botto M,Cook HT,Pickering MC

更新日期：2009-06-01 00:00:00